Key words: cecropin antibacterial peptide broiler growth performance
In recent years, broiler breeding has entered a large-scale farming system. During the feeding process, antibiotics have been widely used, resulting in resistance to many pathogens. The use of antibiotic additives also seriously damages the microbial balance in the intestines of animals, and it is extremely easy to cause drug residues, which seriously endangers the quality of broiler products and endangers human health. These questions
It has aroused people's attention. Since January 2006, the EU has completely banned the use of feed antibiotics in feed. Other countries have also restricted the use of feed antibiotics. In the context of the banned antibiotics, safe use, The high-efficiency, residue-free new feed additive replaces the use of antibiotics in the past with great economic and social benefits.
Antibacterial Peptides are cationic peptides produced by organisms with strong antibacterial activity and are important components of biological congenital immunity. Antibacterial peptides not only directly kill microbes, but also act as a bridge between innate and acquired immune responses through chemotactic dendritic cells, monocytes and memory T cells, and activate the acquired immune system to improve the body. Ability to resist microbial infections [1, 2, 7, 8, 10].
Cecropin antibacterial peptide is a hybrid peptide containing 37 amino acid residues synthesized by our company's senior experts according to Cecropin A and D [9]. And genetically engineered products successfully expressed in Bacillus subtilis. In vitro bacteriostatic test has proved that it can effectively inhibit harmful bacteria such as Escherichia coli, Staphylococcus aureus and Salmonella, and has unique antibacterial properties and growth promoting effects, making it an excellent alternative to antibiotics.
1, materials and methods
1.1 Test animals and grouping
The test used 78,000 healthy broilers and was randomly divided into 6 groups. Two treatments were set up. Each treatment was 3 replicates (group), and each replicate (group) was 13,000. Each group was placed in a chicken house, ie 1 Groups 2, 3, 4, 5, and 6, of which groups 1, 2, and 3 were the control group and groups 4, 5, and 6 were the experimental groups.
1.2 Test site and test time
Test site: A large broiler test site in Beijing.
Test time: July 5, 2010 to August 18, 2010
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